In 1849, Bishop Anastasius Hartmann, who was responsible for the Patna-Bettiah section of the North India Mission, acquired a sizable piece of land (about five acres) in Bankipore where he laid the foundation of a chapel on September 23, 1849.

The Roman Catholic Church, St. Joseph's, was opened in 1850. In 1852, on invitation of Bishop Anastasius Hartmann, the Apostolic Vicar of Patna, a group of five institute Virgin Mary Sisters from Munich Province in Germany came to India. These five sisters were Sisters Maria Groeppner, Angela Hoffman, Aloysia Maher, Antonia Feth and Catherine Schreibman. The sisters landed in Bombay by ship and then set out for Patna. They traveled from Bombay to Patna by bullock cart through the thick jungles. They left Bombay in early September 1852 and reached Patna around February 1853. They established the first IBVM House in Bankipore in 1853, on the bank of River Ganges. The house and school bear the name of Saint Joseph. Bankipore, as the first foundation, was considered the mother house of the Institute in India. St. Joseph's was the only convent between Calcutta and Agra at that time. Initially, in addition to the boarding and day school, there were two orphanages on the school campus. One for native girls and another for European and Eurasian girls. More buildings were added and the institution gradually grew over time.

A Hindi section was founded in 1950.Currently the school is affiliated to ICSE as well as Bihar State Board. It has a 100% pass percentage in ICSE examination board results for many years and also produced several state and city toppers. landed in Bombay by ship and then set out for Patna. They traveled from Bombay to Patna by bullock cart through the thick jungles. They left Bombay in early September 1852 and reached Patna around February 1853. They established the first IBVM House in Bankipore in 1853, on the bank of River Ganges. The house and school bear the name of Saint Joseph. Bankipore, as the first foundation, was considered the mother house of the Institute in India. St. Joseph's was the only convent between Calcutta and Agra at that time. Initially, in addition to the boarding and day school, there were two orphanages on the school campus. One for native girls and another for European and Eurasian girls. More buildings were added and the institution gradually grew over time.